Open AccessProgressive Neurochemical Abnormalities in Cognitive and Motor Subgroups of Amyotrophic Lateral Sclerosis
Author(s) -
Daniel Ta,
Abdullah Ishaque,
Ojas Srivastava,
Chris Hanstock,
Peter Seres,
Dean T. Eurich,
Collin Luk,
Hannah Briemberg,
Richard Frayne,
Angela Genge,
Simon J. Graham,
Lawrence Korngut,
Lorne Zinman,
Sanjay Kalra
Publication year - 2021
Publication title -
neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.91
H-Index - 364
eISSN - 1526-632X
pISSN - 0028-3878
DOI - 10.1212/wnl.0000000000012367
Subject(s) - amyotrophic lateral sclerosis , motor cortex , medicine , prefrontal cortex , neurochemical , upper motor neuron , cardiology , psychology , neuroscience , disease , cognition , stimulation
To evaluate progressive cerebral degeneration in amyotrophic lateral sclerosis (ALS) by assessing alterations in N -acetylaspartate (NAA) ratios in the motor and prefrontal cortex within clinical subgroups of ALS.