Open AccessDevelopment and Validation of a Polygenic Risk Score for Stroke in the Chinese Population
Author(s) -
Xiangfeng Lu,
Xiaoge Niu,
Chong Shen,
Fangchao Liu,
Zhongying Liu,
Keyong Huang,
Laiyuan Wang,
Jianxin Li,
Dongsheng Hu,
Yong Zhao,
Xueli Yang,
Fanghong Lu,
Xiaoqing Liu,
Jie Cao,
Shufeng Chen,
Hongfan Li,
Wei Tang,
Zeying Ren,
Ling Yu,
Xianping Wu,
Xigui Wu,
Ying Liu,
Huan Zhang,
Jianfeng Huang,
Zhibin Hu,
Hongbing Shen,
Cristen J. Willer,
Dongfeng Gu
Publication year - 2021
Publication title -
neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.91
H-Index - 364
eISSN - 1526-632X
pISSN - 0028-3878
DOI - 10.1212/wnl.0000000000012263
Subject(s) - medicine , stroke (engine) , hazard ratio , confidence interval , polygenic risk score , proportional hazards model , population , framingham risk score , prospective cohort study , demography , risk assessment , environmental health , biology , genetics , disease , single nucleotide polymorphism , genotype , sociology , computer science , engineering , gene , mechanical engineering , computer security
To construct a polygenic risk score (PRS) for stroke and evaluate its utility in risk stratification and primary prevention for stroke.