Open AccessDevelopment of a Sensitive Diagnostic Assay for Parkinson Disease Quantifying α-Synuclein–Containing Extracellular Vesicles
Author(s) -
Hong Zhao,
Chen Tian,
Tessandra Stewart,
Patrick Aro,
David Soltys,
Matt Bercow,
Lifu Sheng,
Kayla Borden,
Tarek Khrisat,
Catherine Pan,
Cyrus P. Zabetian,
Elaine R. Peskind,
Joseph F. Quinn,
Thomas J. Montine,
Jan Aasly,
Min Shi,
Jing Zhang
Publication year - 2021
Publication title -
neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.91
H-Index - 364
eISSN - 1526-632X
pISSN - 0028-3878
DOI - 10.1212/wnl.0000000000011853
Subject(s) - flow cytometry , extracellular vesicles , parkinson's disease , medicine , area under the curve , immunoassay , pathology , immunology , antibody , disease , biology , microbiology and biotechnology
To develop a reliable and fast assay to quantify the α-synuclein (α-syn)-containing extracellular vesicles (EVs) in CSF and to assess their diagnostic potential for Parkinson disease (PD).