Open AccessCardiovascular Risk Factors Across the Life Course and Cognitive Decline
Author(s) -
Kristine Yaffe,
Eric Vittinghoff,
Tina Hoang,
Karen A. Matthews,
Sherita Hill Golden,
Adina Zeki Al Hazzouri
Publication year - 2021
Publication title -
neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.91
H-Index - 364
eISSN - 1526-632X
pISSN - 0028-3878
DOI - 10.1212/wnl.0000000000011747
Subject(s) - digit symbol substitution test , cohort , life course approach , cognitive decline , cognition , body mass index , medicine , cohort study , demography , gerontology , blood pressure , psychology , developmental psychology , psychiatry , disease , dementia , alternative medicine , pathology , sociology , placebo
Cardiovascular risk factors (CVRFs) are associated with increased risk of cognitive decline, but little is known about how early adult CVRFs and those across the life course might influence late-life cognition. To test the hypothesis that CVRFs across the adult life course are associated with late-life cognitive changes, we pooled data from 4 prospective cohorts (n = 15,001, ages 18-95).