Open AccessValidation of the Alzheimer Disease Dementia Conversion-Related Pattern as an ATN Biomarker of Neurodegeneration
Author(s) -
Ganna Blazhenets,
Lars Frings,
Yilong Ma,
A Sörensen,
David Eidelberg,
Jens Wiltfang,
Philipp T. Meyer
Publication year - 2021
Publication title -
neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.91
H-Index - 364
eISSN - 1526-632X
pISSN - 0028-3878
DOI - 10.1212/wnl.0000000000011521
Subject(s) - neurodegeneration , dementia , biomarker , frontotemporal dementia , medicine , oncology , hazard ratio , alzheimer's disease , disease , pathology , psychology , biology , confidence interval , biochemistry
To determine whether the Alzheimer disease (AD) dementia conversion-related pattern (ADCRP) on [ 18 F]FDG PET can serve as a valid predictor for the development of AD dementia, the individual expression of the ADCRP (subject score) and its prognostic value were examined in patients with mild cognitive impairment (MCI) and biologically defined AD.