Open AccessAssociation of APOE4 and Clinical Variability in Alzheimer Disease With the Pattern of Tau- and Amyloid-PET
Author(s) -
Renaud La Joie,
Adrienne Visani,
Orit H. LesmanSegev,
Suzanne L. Baker,
Lauren Edwards,
Leonardo Iaccarino,
David N. SoleimaniMeigooni,
Taylor J. Mellinger,
Mustafa Janabi,
Zachary A. Miller,
David C. Perry,
Julie Pham,
Amelia Strom,
Maria Luisa GornoTempini,
Howard J. Rosen,
Bruce L. Miller,
William J. Jagust,
Gil D. Rabinovici
Publication year - 2021
Publication title -
neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.91
H-Index - 364
eISSN - 1526-632X
pISSN - 0028-3878
DOI - 10.1212/wnl.0000000000011270
Subject(s) - primary progressive aphasia , standardized uptake value , clinical dementia rating , medicine , atrophy , entorhinal cortex , posterior cortical atrophy , pathology , alzheimer's disease , neuroscience , grey matter , dementia , disease , positron emission tomography , psychology , white matter , frontotemporal dementia , magnetic resonance imaging , hippocampal formation , radiology
To assess whether Alzheimer disease (AD) clinical presentation and APOE4 relate to the burden and topography of β-amyloid (Aβ) and tau pathologies using in vivo PET imaging.