Open AccessPM 2.5 Associated With Gray Matter Atrophy Reflecting Increased Alzheimer Risk in Older Women
Author(s) -
Diana Younan,
Xinhui Wang,
Ramon Casanova,
Ryan Barnard,
Sarah A. Gaussoin,
Santiago Saldana,
Andrew J. Petkus,
Daniel P. Beavers,
Susan M. Resnick,
JoAnn E. Manson,
Marc L. Serre,
William Vizuete,
Victor W. Henderson,
Bonnie C. Sachs,
Joel Salinas,
Margaret Gatz,
Mark A. Espeland,
Helena C. Chui,
Sally A. Shumaker,
Stéphen R. Rapp,
JiuChiuan Chen
Publication year - 2021
Publication title -
neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.91
H-Index - 364
eISSN - 1526-632X
pISSN - 0028-3878
DOI - 10.1212/wnl.0000000000011149
Subject(s) - parahippocampal gyrus , medicine , atrophy , interquartile range , white matter , cohort , temporal lobe , neuroimaging , magnetic resonance imaging , psychiatry , radiology , epilepsy
To examine whether late-life exposure to PM 2.5 (particulate matter with aerodynamic diameters <2.5-µm) contributes to progressive brain atrophy predictive of Alzheimer's disease (AD) using a community-dwelling cohort of women (aged 70-89) with up to two brain MRI scans (MRI-1: 2005-6; MRI-2: 2010-11).