Open AccessAssociation of midlife vascular risk and AD biomarkers with subsequent cognitive decline
Author(s) -
Corinne Pettigrew,
Anja Soldan,
Jiangxia Wang,
Mei Cheng Wang,
Karissa Arthur,
Abhay Moghekar,
Rebecca F. Gottesman,
Marilyn Albert
Publication year - 2020
Publication title -
neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.91
H-Index - 364
eISSN - 1526-632X
pISSN - 0028-3878
DOI - 10.1212/wnl.0000000000010946
Subject(s) - cognitive decline , medicine , biomarker , cohort , confidence interval , risk factor , oncology , disease , endocrinology , dementia , biology , biochemistry
To determine whether vascular risk and Alzheimer disease (AD) biomarkers have independent or synergistic effects on cognitive decline and whether vascular risk is associated with the accumulation of AD pathology as measured by change in biomarkers over time.