Open AccessEmulating a target trial of statin use and risk of dementia using cohort data
Author(s) -
Ellen C Caniglia,
L Paloma Rojas-Saunero,
Saima Hilal,
Silvan Licher,
Roger Logan,
Bruno H. Ch. Stricker,
M. Arfan Ikram,
Sonja A. Swanson
Publication year - 2020
Publication title -
neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.91
H-Index - 364
eISSN - 1526-632X
pISSN - 0028-3878
DOI - 10.1212/wnl.0000000000010433
Subject(s) - dementia , medicine , statin , confidence interval , cohort , confounding , cohort study , observational study , logistic regression , odds ratio , disease
Observational data can be used to attempt to emulate a target trial of statin use and estimate analogues of intention-to-treat and per protocol effects on dementia risk.