Open AccessTime course and diagnostic utility of NfL, tau, GFAP, and UCH-L1 in subacute and chronic TBI
Author(s) -
Pashtun Shahim,
Adam Politis,
André van der Merwe,
Brian Moore,
Vindhya Ekanayake,
Sara M. Lippa,
YiYu Chou,
Dzung L. Pham,
John A. Butman,
Ramon DiazArrastia,
Henrik Zetterberg,
Kaj Blennow,
Jessica Gill,
David L. Brody,
Leighton Chan
Publication year - 2020
Publication title -
neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.91
H-Index - 364
eISSN - 1526-632X
pISSN - 0028-3878
DOI - 10.1212/wnl.0000000000009985
Subject(s) - traumatic brain injury , glial fibrillary acidic protein , medicine , biomarker , diffusion mri , receiver operating characteristic , gastroenterology , pathology , magnetic resonance imaging , radiology , psychiatry , immunohistochemistry , biology , biochemistry
To determine whether neurofilament light (NfL), glial fibrillary acidic protein (GFAP), tau, and ubiquitin C-terminal hydrolase-L1 (UCH-L1) measured in serum relate to traumatic brain injury (TBI) diagnosis, injury severity, brain volume, and diffusion tensor imaging (DTI) measures of traumatic axonal injury (TAI) in patients with TBI.