Open AccessGenetic overlap and causal inferences between kidney function and cerebrovascular disease
Author(s) -
Sandro Marini,
Marios K. Georgakis,
Jaeyoon Chung,
Jonathan J. Henry,
Martin Dichgans,
Jonathan Rosand,
Rainer Malik,
Christopher Anderson
Publication year - 2020
Publication title -
neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.91
H-Index - 364
eISSN - 1526-632X
pISSN - 0028-3878
DOI - 10.1212/wnl.0000000000009642
Subject(s) - mendelian randomization , renal function , medicine , kidney disease , odds ratio , stroke (engine) , genome wide association study , lacunar stroke , confidence interval , cardiology , bioinformatics , genetics , biology , single nucleotide polymorphism , genotype , genetic variants , ischemia , ischemic stroke , gene , mechanical engineering , engineering
Leveraging large-scale genetic data, we aimed to identify shared pathogenic mechanisms and causal relationships between impaired kidney function and cerebrovascular disease phenotypes.