Open AccessEffect of ApoE isoforms on mitochondria in Alzheimer disease
Author(s) -
Jun Yin,
Eric M. Reiman,
Thomas G. Beach,
Geidy E. Serrano,
Marwan N. Sabbagh,
Megan Nielsen,
Richard J. Caselli,
Jiong Shi
Publication year - 2020
Publication title -
neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.91
H-Index - 364
eISSN - 1526-632X
pISSN - 0028-3878
DOI - 10.1212/wnl.0000000000009582
Subject(s) - sirt3 , mitochondrial biogenesis , mfn2 , biology , oxidative stress , apolipoprotein e , mitochondrion , alzheimer's disease , microbiology and biotechnology , neuroscience , endocrinology , medicine , sirtuin , biochemistry , disease , mitochondrial fusion , acetylation , mitochondrial dna , gene
To test the hypothesis that ApoE isoforms affect mitochondrial structure and function that are related to cognitive impairment in Alzheimer disease (AD), we systematically investigated the effects of ApoE isoforms on mitochondrial biogenesis and dynamics, oxidative stress, synapses, and cognitive performance in AD.