Open AccessIdentification of distinctive interferon gene signatures in different types of myositis
Author(s) -
Iago PinalFernandez,
María Casal-Domínguez,
Assia Derfoul,
Katherine Pak,
Paul H. Plötz,
Frederick W. Miller,
José C. Milisenda,
Josep María Grau-Junyent,
Albert Selva-O’Callaghan,
Julie J Paik,
Jemima Albayda,
Lisa ChristopherStine,
Thomas E. Lloyd,
Andrea M. Corse,
Andrew L. Mammen
Publication year - 2019
Publication title -
neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.91
H-Index - 364
eISSN - 1526-632X
pISSN - 0028-3878
DOI - 10.1212/wnl.0000000000008128
Subject(s) - myositis , dermatomyositis , inclusion body myositis , muscle biopsy , gene , interferon , myopathy , biology , medicine , pathology , immunology , biopsy , genetics
Activation of the type 1 interferon (IFN1) pathway is a prominent feature of dermatomyositis (DM) muscle and may play a role in the pathogenesis of this disease. However, the relevance of the IFN1 pathway in patients with other types of myositis such as the antisynthetase syndrome (AS), immune-mediated necrotizing myopathy (IMNM), and inclusion body myositis (IBM) is largely unknown. Moreover, the activation of the type 2 interferon (IFN2) pathway has not been comprehensively explored in myositis. In this cross-sectional study, our objective was to determine whether IFN1 and IFN2 pathways are differentially activated in different types of myositis by performing RNA sequencing on muscle biopsy samples from 119 patients with DM, IMNM, AS, or IBM and on 20 normal muscle biopsies.