Open AccessMotor cortex inhibition and modulation in children with ADHD
Author(s) -
Donald L. Gilbert,
David Huddleston,
Steve W. Wu,
Ernest V. Pedapati,
Paul S. Horn,
Kathryn Hirabayashi,
Deanna Crocetti,
Eric M. Wassermann,
Stewart H. Mostofsky
Publication year - 2019
Publication title -
neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.91
H-Index - 364
eISSN - 1526-632X
pISSN - 0028-3878
DOI - 10.1212/wnl.0000000000007899
Subject(s) - transcranial magnetic stimulation , audiology , primary motor cortex , motor cortex , stop signal , psychology , attention deficit hyperactivity disorder , cognition , neuroscience , medicine , stimulation , physical medicine and rehabilitation , psychiatry , electrical engineering , engineering , latency (audio)
Compared to typically developing (TD) peers, children with attention-deficit/hyperactivity disorder (ADHD) consistently demonstrate impaired transcranial magnetic stimulation (TMS)-evoked short interval cortical inhibition (SICI) of motor evoked potentials (MEPs) in resting motor cortex (M1). To determine whether perturbed M1 physiology also reflects clinically relevant behavioral dysfunction, we evaluated M1 physiology during a cognitive control task taxing motor response selection/inhibition.