Open AccessRole of Optical Coherence Tomography in Identifying Retinal Biomarkers in Frontotemporal Dementia
Author(s) -
Omar Moinuddin,
Nikhila S. Khandwala,
Kelly Z. Young,
Sanjana Sathrasala,
Sami J. Barmada,
Roger L. Albin,
Cagri G Besirli
Publication year - 2021
Publication title -
neurology. clinical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.674
H-Index - 29
eISSN - 2163-0933
pISSN - 2163-0402
DOI - 10.1212/cpj.0000000000001041
Subject(s) - frontotemporal dementia , dementia , biomarker , medicine , neurodegeneration , neuroscience , semantic dementia , optical coherence tomography , dementia with lewy bodies , disease , frontotemporal lobar degeneration , retinal , psychology , pathology , ophthalmology , biology , genetics
Frontotemporal dementia (FTD) is often misdiagnosed or recognized late. Clinical heterogeneity and overlap with other dementias impede accurate diagnosis. FTD biomarkers are limited, expensive, and invasive. We present a narrative review of the current literature focused on optical coherence tomography (OCT) to identify retinal biomarkers of dementia, discuss OCT findings in FTD, and explore the implications of an FTD-specific ocular biomarker for research and patient care.