Open AccessNeurofilament Light Chain Related to Longitudinal Decline in Frontotemporal Lobar Degeneration
Author(s) -
Jiasi Vicky Zhang,
David J. Irwin,
Kaj Blennow,
Henrik Zetterberg,
Edward B. Lee,
Leslie M. Shaw,
Katya Rascovsky,
Lauren Massimo,
Corey T. McMillan,
Alice ChenPlotkin,
Lauren Elman,
Virginia M.Y. Lee,
Leo McCluskey,
Jon B. Toledo,
Daniel Weintraub,
David A. Wolk,
John Q. Trojanowski,
Murray Grossman
Publication year - 2021
Publication title -
neurology. clinical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.674
H-Index - 29
eISSN - 2163-0933
pISSN - 2163-0402
DOI - 10.1212/cpj.0000000000000959
Subject(s) - frontotemporal lobar degeneration , cohort , cognitive decline , longitudinal study , context (archaeology) , psychology , medicine , pathology , oncology , disease , frontotemporal dementia , dementia , biology , paleontology
Accurate diagnosis and prognosis of frontotemporal lobar degeneration (FTLD) during life is an urgent concern in the context of emerging disease-modifying treatment trials. Few CSF markers have been validated longitudinally in patients with known pathology, and we hypothesized that CSF neurofilament light chain (NfL) would be associated with longitudinal cognitive decline in patients with known FTLD-TAR DNA binding protein ~43kD (TDP) pathology.