Open AccessCarpal tunnel syndrome and associated symptoms as first manifestation of hATTR amyloidosis
Author(s) -
Chafic Karam,
Dessislava Dimitrova,
Megan Christ,
Stephen B. Heitner
Publication year - 2019
Publication title -
neurology. clinical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.674
H-Index - 29
eISSN - 2163-0933
pISSN - 2163-0402
DOI - 10.1212/cpj.0000000000000640
Subject(s) - medicine , amyloidosis , carpal tunnel syndrome , polyneuropathy , neurology , disease , dysautonomia , pediatrics , dermatology , surgery , psychiatry
Hereditary transthyretin amyloidosis (hATTR) is associated with significant morbidity and mortality. Early diagnosis and treatment are essential to improve patient's outcome. Carpal tunnel syndrome (CTS) is a common complication of hATTR amyloidosis. However, because CTS is also common in the general population, we wanted to assess whether CTS, when associated with systemic manifestations, could help direct physicians to screen for TTR gene mutation and early diagnosis.