Open AccessAltered language processing in autosomal dominant partial epilepsy with auditory features
Author(s) -
Ruth Ottman,
Lisa R. Rosenberger,
Anto Bagić,
Kay Kamberakis,
Eva K. Ritzl,
A. M. Wohlschläger,
Sadat Shamim,
Susumu Satô,
Clarissa J. Liew,
William D. Gaillard,
Edythe Wiggs,
Madison M. Berl,
Patricia Reeves-Tyer,
Errol Baker,
John A. Butman,
William H. Theodore
Publication year - 2008
Publication title -
neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.91
H-Index - 364
eISSN - 1526-632X
pISSN - 0028-3878
DOI - 10.1212/01.wnl.0000336923.29538.5b
Subject(s) - magnetoencephalography , epilepsy , audiology , psychology , neuroscience , functional magnetic resonance imaging , ictal , partial epilepsy , medicine , electroencephalography
Autosomal dominant partial epilepsy with auditory features (ADPEAF) is an idiopathic focal epilepsy syndrome with auditory symptoms or receptive aphasia as major ictal manifestations, frequently associated with mutations in the leucine-rich, glioma inactivated 1 (LGI1) gene. Although affected subjects do not have structural abnormalities detected on routine MRI, a lateral temporal malformation was identified through high resolution MRI in one family. We attempted to replicate this finding and to assess auditory and language processing in ADPEAF using fMRI and magnetoencephalography (MEG).