Open AccessImaging amyloid deposition in Lewy body diseases
Author(s) -
Stephen N. Gomperts,
Dorene M. Rentz,
Erin K. Moran,
J. Alex Becker,
Joseph J. Locascio,
William E. Klunk,
C. A. Mathis,
David R. Elmaleh,
Timothy M. Shoup,
Alan J. Fischman,
Bradley T. Hyman,
John H. Growdon,
Keith A. Johnson
Publication year - 2008
Publication title -
neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.91
H-Index - 364
eISSN - 1526-632X
pISSN - 0028-3878
DOI - 10.1212/01.wnl.0000326146.60732.d6
Subject(s) - dementia with lewy bodies , pittsburgh compound b , dementia , precuneus , pathology , lewy body , amyloid (mycology) , psychology , alzheimer's disease , medicine , parkinson's disease , neuroscience , disease , cognition
Extrapyramidal motor symptoms precede dementia in Parkinson disease (PDD) by many years, whereas dementia occurs early in dementia with Lewy bodies (DLB). Despite this clinical distinction, the neuropsychological and neuropathologic features of these conditions overlap. In addition to widespread distribution of Lewy bodies, both diseases have variable burdens of neuritic plaques and neurofibrillary tangles characteristic of Alzheimer disease (AD).