Open AccessTumour targeting: biological factors and formulation advances in injectable lipid nanoparticles
Author(s) -
Shenoy V. S.,
Vijay I. K.,
Murthy R. S. R.
Publication year - 2005
Publication title -
journal of pharmacy and pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.745
H-Index - 118
eISSN - 2042-7158
pISSN - 0022-3573
DOI - 10.1211/0022357055894
Subject(s) - solid lipid nanoparticle , drug delivery , medicine , drug , pharmacology , targeted drug delivery , drug carrier , biological drugs , nanotechnology , pathology , materials science , disease
Cancer chemotherapeutic agents are often administered systemically. Following systemic administration, numerous biological factors associated with the tumours influence the delivery of the drugs to the tumours. These factors have been extensively studied for the last 2 decades. The influence of these biological factors has brought about a drastic change in the design of drug delivery systems to solid tumours. This review discusses the various biological factors influencing drug delivery to tumours and the subsequent development of injectable delivery systems (i.e., lipid‐based nanoparticles (SLNs)) for adequate delivery of drug to solid tumours.