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To determine the capacity of the chicken c-erbA (cTR-alpha) gene product in regulating expression of known thyroid hormone-responsive genes, both the cTR-alpha and the viral v-erbA genes were expressed in FAO cells, a rat hepatoma cell line defective for functional thyroid hormone receptors. Upon nuclear expression of the cTR-alpha protein the cells become responsive to thyroid hormone, as detected by expression of a number of genes (malic enzyme, phosphoenolpyruvate carboxykinase, and Na+/K(+)-ATPase) reported to be indirectly induced by the hormone in vivo. In addition, our data show that the c-erbA product directly activates the Moloney murine leukemia virus promoter in a ligand-dependent manner. The data show that the chicken c-erbA-alpha protein can modulate the expression of rat genes under either direct or indirect control by thyroid hormone.

molecular endocrinology

The Chicken c-<i>erb</i>A α-Product Induces Expression of Thyroid Hormone-Responsive Genes in 3,5,3′-Triiodothyronine Receptor- Deficient Rat Hepatoma Cells

The Chicken c-erbA α-Product Induces Expression of Thyroid Hormone-Responsive Genes in 3,5,3′-Triiodothyronine Receptor- Deficient Rat Hepatoma Cells