Prolactin receptor is associated with c-src kinase in rat liver | Zendy

Juan José Berlanga | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Prolactin receptor is associated with c-src kinase in rat liver

Author(s) -

Juan José Berlanga

Publication year - 1995

Publication title -

molecular endocrinology

Language(s) - English

Resource type - Journals

eISSN - 1944-9917

pISSN - 0888-8809

DOI - 10.1210/me.9.11.1461

Subject(s) - biology , proto oncogene tyrosine protein kinase src , prolactin , prolactin receptor , kinase , receptor , microbiology and biotechnology , cancer research , endocrinology , genetics , hormone

The mechanism of action of the pituitary hormone PRL was studied in hepatocytes of lactating rats. PRL receptor immune complexes obtained from liver lysates have an associated tyrosine kinase activity. The tyrosine kinase has been identified in isolated hepatocytes as pp60c-src. Incubation of hepatocytes with PRL induces the association of PRL receptor with pp60c-src and the resultant stimulation of its tyrosine kinase activity. Furthermore, PRL stimulates the gene expression of c-fos, c-jun, and c-src. All of these findings support the idea that the pp60c-src tyrosine kinase participates in the early steps of the PRL intracellular signaling that promotes cell growth in liver cells.This work was supported by grants from the DGICYT (PM91-0223 and PB93-0136), CAM (C137/91and C263/91A), and the Ramón Areces Foundation.Peer Reviewe

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research