Open AccessSmall-Molecule “BRCA1-Mimetics” Are Antagonists of Estrogen Receptor-α
Author(s) -
Yanfen Ma,
York Tomita,
Anju Preet,
Robert Clarke,
Erikah Englund,
Scott Grindrod,
Shyam Nathan,
Eliseu De Oliveira,
Milton L. Brown,
Eliot M. Rosen
Publication year - 2014
Publication title -
molecular endocrinology
Language(s) - English
Resource type - Journals
eISSN - 1944-9917
pISSN - 0888-8809
DOI - 10.1210/me.2014-1146
Subject(s) - antiestrogen , estrogen receptor , fulvestrant , tamoxifen , biology , small molecule , pharmacophore , selective estrogen receptor modulator , estrogen , pharmacology , context (archaeology) , coactivator , estrogen receptor alpha , receptor , cancer research , endocrinology , biochemistry , breast cancer , cancer , transcription factor , genetics , paleontology , gene
Resistance to conventional antiestrogens is a major cause of treatment failure and, ultimately, death in breast cancer.