Small-Molecule “BRCA1-Mimetics” Are Antagonists of Estrogen Receptor-α | Zendy

Yongxian Ma | Zendy; York Tomita | Zendy; Anju Preet | Zendy; Robert Clarke | Zendy; Erikah Englund | Zendy; Scott Grindrod | Zendy; Shyam Nathan | Zendy; Eliseu De Oliveira | Zendy; Milton L. Brown | Zendy; Eliot M. Rosen | Zendy

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Small-Molecule “BRCA1-Mimetics” Are Antagonists of Estrogen Receptor-α

Author(s) -

Yongxian Ma,

York Tomita,

Anju Preet,

Robert Clarke,

Erikah Englund,

Scott Grindrod,

Shyam Nathan,

Eliseu De Oliveira,

Milton L. Brown,

Eliot M. Rosen

Publication year - 2014

Publication title -

molecular endocrinology

Language(s) - English

Resource type - Journals

eISSN - 1944-9917

pISSN - 0888-8809

DOI - 10.1210/me.2014-1146

Subject(s) - antiestrogen , estrogen receptor , fulvestrant , tamoxifen , biology , small molecule , pharmacophore , selective estrogen receptor modulator , estrogen , pharmacology , context (archaeology) , coactivator , estrogen receptor alpha , receptor , cancer research , endocrinology , biochemistry , breast cancer , cancer , transcription factor , genetics , paleontology , gene

Resistance to conventional antiestrogens is a major cause of treatment failure and, ultimately, death in breast cancer.

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