Active Cushing Disease Is Characterized by Increased Adipose Tissue Macrophage Presence | Zendy

Irene T. Lee | Zendy; Alexandria Atuahene | Zendy; Hale ERGİN EĞRİTAĞ | Zendy; Ling Wang | Zendy; Michael Donovan | Zendy; Christoph Buettner | Zendy; Eliza B. Geer | Zendy

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Active Cushing Disease Is Characterized by Increased Adipose Tissue Macrophage Presence

Author(s) -

Irene T. Lee,

Alexandria Atuahene,

Hale ERGİN EĞRİTAĞ,

Ling Wang,

Michael Donovan,

Christoph Buettner,

Eliza B. Geer

Publication year - 2019

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2018-02552

Subject(s) - proinflammatory cytokine , medicine , endocrinology , cd68 , inflammation , adipose tissue , insulin resistance , systemic inflammation , immunohistochemistry , insulin

Although glucocorticoids (GCs) have potent anti-inflammatory actions, patients with hypercortisolism due to Cushing disease (CD) have increased circulating proinflammatory cytokines that may contribute to their insulin resistance and cardiovascular disease. The mechanisms and tissues that account for the increased systemic inflammation in patients with CD are unknown.

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