Massive Ovarian Growth in a Woman With Severe Insulin-Resistant Polycystic Ovary Syndrome Receiving GnRH Analogue | Zendy

Prapti Singh | Zendy; Ariela Agress | Zendy; V. Madrigal | Zendy; Clara E. Magyar | Zendy; Nora Ostrzega | Zendy; Gregorio D. Chazenbalk | Zendy; Daniel A. Dumesic | Zendy

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Massive Ovarian Growth in a Woman With Severe Insulin-Resistant Polycystic Ovary Syndrome Receiving GnRH Analogue

Author(s) -

Prapti Singh,

Ariela Agress,

V. Madrigal,

Clara E. Magyar,

Nora Ostrzega,

Gregorio D. Chazenbalk,

Daniel A. Dumesic

Publication year - 2019

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2018-02464

Subject(s) - endocrinology , polycystic ovary , medicine , insulin resistance , hyperinsulinemia , hyperandrogenism , antral follicle , metformin , biology , insulin , ovary

Ovarian hyperandrogenism from polycystic ovary syndrome (PCOS) and hyperinsulinemia from insulin resistance are modulators of ovarian follicle development. We report on a woman with PCOS and hyperandrogenism and severe insulin resistance from metabolic syndrome who received long-term GnRH analogue therapy preceding bilateral salpingo-oophorectomy for massive ovarian enlargement. Ovarian histological examination showed proliferating granulosa cells within antral follicles coexistent with serous cystadenofibromas, demonstrating a unique link between hyperinsulinemia and granulosa cell mitogenesis.

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