Adrenal Vein Sampling Lateralization Despite Mineralocorticoid Receptor Antagonists Exposure in Primary Aldosteronism | Zendy

Aya T Nanba | Zendy; Taweesak Wannachalee | Zendy; James J. Shields | Zendy; James Brian Byrd | Zendy; William E. Rainey | Zendy; Richard J. Auchus | Zendy; Adina F. Turcu | Zendy

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Adrenal Vein Sampling Lateralization Despite Mineralocorticoid Receptor Antagonists Exposure in Primary Aldosteronism

Author(s) -

Aya T Nanba,

Taweesak Wannachalee,

James J. Shields,

James Brian Byrd,

William E. Rainey,

Richard J. Auchus,

Adina F. Turcu

Publication year - 2018

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2018-01299

Subject(s) - primary aldosteronism , medicine , mineralocorticoid receptor , aldosterone , adrenalectomy , hyperaldosteronism , cohort , urology , mineralocorticoid , endocrinology

Many antihypertensive medications modulate the renin-angiotensin-aldosterone system, possibly skewing the diagnosis and subtyping of primary aldosteronism (PA). Particularly, mineralocorticoid receptor antagonists (MRA) might raise renin and stimulate aldosterone synthesis from nonautonomous areas, potentially obscuring lateralization on adrenal vein sampling (AVS). Withdrawal of MRA in severe PA, however, can precipitate hypokalemia and/or hypertension and therefore is not always practical.

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