Open AccessAnemia in Patients With Resistance to Thyroid Hormone α: A Role for Thyroid Hormone Receptor α in Human Erythropoiesis
Author(s) -
Anja L M van Gucht,
Marcel E Meima,
Carla Moran,
Maura Agostini,
Anna TylkiSzymańska,
M. Krajewska,
Krystyna Chrzanowska,
Alexandra Efthymiadou,
Dionisios Chrysis,
Korcan Demir,
Willy Visser,
Theo J. Visser,
Krishna Chatterjee,
Thamar B. van Dijk,
Robin P. Peeters
Publication year - 2017
Publication title -
the journal of clinical endocrinology and metabolism/journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2017-00840
Subject(s) - erythropoiesis , medicine , endocrinology , progenitor cell , biology , thyroid , immunology , anemia , stem cell , microbiology and biotechnology
Patients with resistance to thyroid hormone (TH) α (RTHα) are characterized by growth retardation, macrocephaly, constipation, and abnormal thyroid function tests. In addition, almost all RTHα patients have mild anemia, the pathogenesis of which is unknown. Animal studies suggest an important role for TH and TH receptor (TR)α in erythropoiesis.