Investigating the KNDy Hypothesis in Humans by Coadministration of Kisspeptin, Neurokinin B, and Naltrexone in Men | Zendy

Shakunthala Narayanaswamy | Zendy; Julia Prague | Zendy; Chan. Jayasena | Zendy; Deborah Papadopoulou | Zendy; Maria Mizamtsidi | Zendy; Amar Shah | Zendy; Paul Bassett | Zendy; Alexander Comninos | Zendy; Ali Abbara | Zendy; Stephen R. Bloom | Zendy; Johannes D. Veldhuis | Zendy; Waljit S. Dhillo | Zendy

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Investigating the KNDy Hypothesis in Humans by Coadministration of Kisspeptin, Neurokinin B, and Naltrexone in Men

Author(s) -

Shakunthala Narayanaswamy,

Julia Prague,

Chan. Jayasena,

Deborah Papadopoulou,

Maria Mizamtsidi,

Amar Shah,

Paul Bassett,

Alexander Comninos,

Ali Abbara,

Stephen R. Bloom,

Johannes D. Veldhuis,

Waljit S. Dhillo

Publication year - 2016

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2016-1911

Subject(s) - neurokinin b , kisspeptin , endocrinology , medicine , dynorphin , naltrexone , dynorphin a , gonadotropin , gonadotropin releasing hormone , blood sampling , neuropeptide , luteinizing hormone , placebo , antagonist , opioid peptide , opioid , substance p , hormone , receptor , alternative medicine , pathology

A subpopulation of hypothalamic neurons colocalize three neuropeptides, namely kisspeptin, neurokinin B (NKB), and dynorphin, collectively termed KNDy neurons. Animal studies suggest they interact to affect pulsatile GnRH release (KNDy hypothesis); kisspeptin stimulates, NKB modulates, and dynorphin (an opioid) inhibits.

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