Neuroendocrine Tumor of the Pancreas as a Manifestation of Cowden Syndrome: A Case Report | Zendy

Vladimir Neychev | Zendy; Samira M. Sadowski | Zendy; Jinfang Zhu | Zendy; Michael Allgäeuer | Zendy; Katja Kilian | Zendy; Paul S. Meltzer | Zendy; Electron Kebebew | Zendy

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Neuroendocrine Tumor of the Pancreas as a Manifestation of Cowden Syndrome: A Case Report

Author(s) -

Vladimir Neychev,

Samira M. Sadowski,

Jinfang Zhu,

Michael Allgäeuer,

Katja Kilian,

Paul S. Meltzer,

Electron Kebebew

Publication year - 2015

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2015-3684

Subject(s) - cowden syndrome , pancreas , medicine , neuroendocrine tumors , pathology , pten , biology , apoptosis , pi3k/akt/mtor pathway , biochemistry

Germline mutations in the phosphatase and tensin homolog (PTEN) tumor suppressor gene are found in the majority of patients with Cowden syndrome (CS), who have an increased risk of breast, thyroid, and endometrial cancer. According to our current understanding of genetic changes in the PTEN gene and the resultant phenotypic features of CS, pancreatic neuroendocrine tumors (NETs) are not considered part of the clinical spectrum of CS.

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