Estrogens and Their Genotoxic Metabolites Are Increased in Obese Prepubertal Girls | Zendy

Nelly Mauras | Zendy; Richard J. Santen | Zendy; Gerardo ColónOtero | Zendy; Jobayer Hossain | Zendy; Qingqing Wang | Zendy; Clementina Mesaros | Zendy; Ian A. Blair | Zendy

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Estrogens and Their Genotoxic Metabolites Are Increased in Obese Prepubertal Girls

Author(s) -

Nelly Mauras,

Richard J. Santen,

Gerardo ColónOtero,

Jobayer Hossain,

Qingqing Wang,

Clementina Mesaros,

Ian A. Blair

Publication year - 2015

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2015-1495

Subject(s) - medicine , endocrinology , estrogen , quartile , body mass index , estrone , obesity , breast cancer , chemistry , lean body mass , cancer , body weight , confidence interval

Estrogen levels and their metabolites are higher in obese vs lean postmenopausal women, and obesity increases breast cancer risk. Quinone derivatives of 4-hydroxylated estrogen metabolites, independently of the estrogen receptor, cause depurination and impaired DNA repair (genotoxic). 16α-Hydroxy (16α-OH)-estrone (E1), eg, promotes tumor proliferation and 2-methoxy-estradiol (E2) may be chemoprotective. Childhood obesity increases breast cancer death risk in women, but levels of estrogen derivatives had not been previously studied in young children.

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