Open AccessDifferential Response to High Glucose in Skin Fibroblasts of Monozygotic Twins Discordant for Type 1 Diabetes
Author(s) -
M. Luiza Caramori,
Youngki Kim,
Rama Natarajan,
Jason H. Moore,
Stephen S. Rich,
Josyf C. Mychaleckyj,
Ryoko Kuriyama,
David T. Kirkpatrick,
Michael Mauer
Publication year - 2015
Publication title -
the journal of clinical endocrinology and metabolism/journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2014-4467
Subject(s) - type 1 diabetes , monozygotic twin , type 2 diabetes , medicine , differential (mechanical device) , diabetes mellitus , endocrinology , biology , genetics , physics , thermodynamics
Most epigenetic studies in diabetes compare normal cells in "high glucose" (HG) to cells in "normal glucose" (NG) and cells returned from HG to NG. Here we challenge this approach.