Open AccessThe Effect of Leptin Replacement on Parathyroid Hormone, RANKL-Osteoprotegerin Axis, and Wnt Inhibitors in Young Women With Hypothalamic Amenorrhea
Author(s) -
JooPin Foo,
Stergios A. Pοlyzos,
Athanasios D. Anastasilakis,
Sharon H. Chou,
Christos S. Mantzoros
Publication year - 2014
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2014-2491
Subject(s) - medicine , endocrinology , sclerostin , osteoprotegerin , leptin , rankl , chemistry , activator (genetics) , obesity , wnt signaling pathway , receptor , biochemistry , gene
Recombinant leptin (metreleptin) treatment restores bone mineral density in women with hypothalamic amenorrhea (HA), a condition characterized by hypoleptinemia, which has adverse impact on bone health.
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