Open AccessPersistent Apparent Pancreatic β-Cell Defects in Premenarchal PCOS Relatives
Author(s) -
Laura Torchen,
Naomi R. Fogel,
Wendy J. Brickman,
Rodis Paparodis,
Andrea Dunaif
Publication year - 2014
Publication title -
the journal of clinical endocrinology and metabolism/journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2014-1474
Subject(s) - medicine , endocrinology , polycystic ovary , insulin , body mass index , androgen , diabetes mellitus , insulin resistance , glucose tolerance test , glucose homeostasis , biology , hormone
Polycystic ovary syndrome confers an increased risk for type 2 diabetes in affected women as early as adolescence. First-degree relatives (FDRs) of affected women are at increased risk for associated reproductive and metabolic phenotypes.