Autoimmune Mechanisms Activating the Angiotensin AT1 Receptor in 'Primary' Aldosteronism | Zendy

David C. Kem | Zendy; Hongliang Li | Zendy; Carolina VelardeMiranda | Zendy; Campbell Liles | Zendy; Megan VanderlindeWood | Zendy; Allison Galloway | Zendy; Muneer Khan | Zendy; Caitlin Zillner | Zendy; Alexandria Benbrook | Zendy; Veitla Rao | Zendy; Celso E. Gómez-Sánchez | Zendy; Madeleine W. Cunningham | Zendy; Xichun Yu | Zendy

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Autoimmune Mechanisms Activating the Angiotensin AT1 Receptor in 'Primary' Aldosteronism

Author(s) -

David C. Kem,

Hongliang Li,

Carolina VelardeMiranda,

Campbell Liles,

Megan VanderlindeWood,

Allison Galloway,

Muneer Khan,

Caitlin Zillner,

Alexandria Benbrook,

Veitla Rao,

Celso E. Gómez-Sánchez,

Madeleine W. Cunningham,

Xichun Yu

Publication year - 2014

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2013-3282

Subject(s) - losartan , medicine , endocrinology , aldosterone , autoantibody , angiotensin ii , angiotensin ii receptor type 1 , renin–angiotensin system , primary aldosteronism , receptor , pathophysiology , immunology , antibody , blood pressure

The mechanisms causing excessive aldosterone production and hypertension in primary aldosteronism (PA) are complex and often incompletely recognized. Autoantibodies to the angiotensin AT1 receptor (AT1R) have been reported in some PA patients with an aldosterone-producing adenoma but not with idiopathic adrenal hyperplasia.

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