Dominant Suppression of Addison's Disease Associated with HLA-B15 | Zendy

Peter R. Baker | Zendy; Erin E. Baschal | Zendy; P. Fain | Zendy; Priyaanka Nanduri | Zendy; Taylor M. Triolo | Zendy; Janet Siebert | Zendy; Taylor Armstrong | Zendy; Sunanda Babu | Zendy; Marian Rewers | Zendy; Peter A. Gottlieb | Zendy; Jennifer M. Barker | Zendy; George S. Eisenbarth | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Dominant Suppression of Addison's Disease Associated with HLA-B15

Author(s) -

Peter R. Baker,

Erin E. Baschal,

P. Fain,

Priyaanka Nanduri,

Taylor M. Triolo,

Janet Siebert,

Taylor Armstrong,

Sunanda Babu,

Marian Rewers,

Peter A. Gottlieb,

Jennifer M. Barker,

George S. Eisenbarth

Publication year - 2011

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2010-2964

Subject(s) - human leukocyte antigen , immunology , haplotype , autoantibody , genotype , hla dq , single nucleotide polymorphism , allele , population , type 1 diabetes , medicine , major histocompatibility complex , diabetes mellitus , biology , genetics , antigen , antibody , endocrinology , gene , environmental health

Autoimmune Addison's disease (AD) is the major cause of primary adrenal failure in developed nations. Autoantibodies to 21-hydroxylase (21OH-AA) are associated with increased risk of progression to AD. Highest genetic risk is associated with the Major Histocompatibility region (MHC), specifically human leukocyte antigen (HLA)-DR3 haplotypes (containing HLA-B8) and HLA-DR4.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research