Open AccessNonoxidative Free Fatty Acid Disposal Is Greater in Young Women than Men
Author(s) -
Christina Koutsari,
Rita Basu,
Robert A. Rizza,
K. Sreekumaran Nair,
Sundeep Khosla,
Michael D. Jensen
Publication year - 2011
Publication title -
the journal of clinical endocrinology and metabolism/journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2010-1651
Subject(s) - medicine , endocrinology , triglyceride , fatty acid , context (archaeology) , hypertriglyceridemia , insulin , chemistry , biology , cholesterol , biochemistry , paleontology
Large increases in systemic free fatty acid (FFA) availability in the absence of a corresponding increase in fatty acid oxidation can create a host of metabolic abnormalities. These adverse responses are thought to be the result of fatty acids being shunted into hepatic very low-density lipoprotein-triglyceride production and/or intracellular lipid storage and signaling pathways because tissues are forced to increase nonoxidative FFA disposal.