Significant Human β-Cell Turnover Is Limited to the First Three Decades of Life as Determined byin VivoThymidine Analog Incorporation and Radiocarbon Dating | Zendy

Shira Perl | Zendy; Jake A. Kushner | Zendy; Bruce A. Buchholz | Zendy; Alan K. Meeker | Zendy; Geneva M. Stein | Zendy; Min-Kang Hsieh | Zendy; Martha Kirby | Zendy; Susanne Pechhold | Zendy; E. H. Liu | Zendy; David M. Harlan | Zendy; John F. Tisdale | Zendy

Open Access

Significant Human β-Cell Turnover Is Limited to the First Three Decades of Life as Determined byin VivoThymidine Analog Incorporation and Radiocarbon Dating

Author(s) -

Shira Perl,

Jake A. Kushner,

Bruce A. Buchholz,

Alan K. Meeker,

Geneva M. Stein,

Min-Kang Hsieh,

Martha Kirby,

Susanne Pechhold,

E. H. Liu,

David M. Harlan,

John F. Tisdale

Publication year - 2010

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2010-0932

Subject(s) - thymidine , in vivo , cell , biology , bromodeoxyuridine , islet , dna , andrology , endocrinology , medicine , diabetes mellitus , physiology , cell growth , genetics

Diabetes mellitus results from an absolute or relative deficiency of insulin-producing pancreatic β-cells. The turnover rate of adult human β-cells remains unknown. We employed two techniques to examine adult human islet β-cell turnover and longevity in vivo.

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