Effects of Insulin-Like Growth Factor (IGF)-I/IGF-Binding Protein-3 Treatment on Glucose Metabolism and Fat Distribution in Human Immunodeficiency Virus-Infected Patients with Abdominal Obesity and Insulin Resistance | Zendy

Madhu N. Rao | Zendy; Kathleen Mulligan | Zendy; Viva Tai | Zendy; Michael Wen | Zendy; Artem Dyachenko | Zendy; Melissa E. Weinberg | Zendy; Xiaojuan Li | Zendy; Thomas Lang | Zendy; Carl Grünfeld | Zendy; JeanMarc Schwarz | Zendy; Morris Schambelan | Zendy

Open Access

Effects of Insulin-Like Growth Factor (IGF)-I/IGF-Binding Protein-3 Treatment on Glucose Metabolism and Fat Distribution in Human Immunodeficiency Virus-Infected Patients with Abdominal Obesity and Insulin Resistance

Author(s) -

Madhu N. Rao,

Kathleen Mulligan,

Viva Tai,

Michael Wen,

Artem Dyachenko,

Melissa E. Weinberg,

Xiaojuan Li,

Thomas Lang,

Carl Grünfeld,

JeanMarc Schwarz,

Morris Schambelan

Publication year - 2010

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2009-2502

Subject(s) - insulin resistance , medicine , endocrinology , abdominal obesity , insulin like growth factor , insulin , human immunodeficiency virus (hiv) , obesity , abdominal fat , metabolism , carbohydrate metabolism , growth factor , distribution (mathematics) , biology , virology , metabolic syndrome , receptor , mathematical analysis , mathematics

HIV-infected patients on antiretroviral therapy are at increased risk for excess visceral adiposity and insulin resistance. Treatment with GH decreases visceral adiposity but worsens glucose metabolism. IGF-I, which mediates many of the effects of GH, improves insulin sensitivity in HIV-negative individuals.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research