Open AccessComparison of Simvastatin and Metformin in Treatment of Polycystic Ovary Syndrome: Prospective Randomized Trial
Author(s) -
Beata Banaszewska,
Leszek Pawełczyk,
Robert Spaczyński,
Antoni J. Dulęba
Publication year - 2009
Publication title -
the journal of clinical endocrinology and metabolism/journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2009-1674
Subject(s) - simvastatin , metformin , polycystic ovary , medicine , endocrinology , free androgen index , hyperandrogenism , testosterone (patch) , statin , metabolic syndrome , prospective cohort study , insulin resistance , diabetes mellitus
Polycystic ovary syndrome (PCOS) is characterized by ovarian dysfunction and hyperandrogenism; it is also associated with increased cardiovascular risks such as adverse lipid profile and endothelial dysfunction. Metformin and, more recently, statins have been shown to improve endocrine and metabolic aspects of PCOS.