Long-Term Growth Hormone Therapy Changes the Natural History of Body Composition and Motor Function in Children with Prader-Willi Syndrome | Zendy

Aaron L. Carrel | Zendy; S Myers | Zendy; Barbara Y. Whitman | Zendy; Jens C. Eickhoff | Zendy; David B. Allen | Zendy

Open Access

Long-Term Growth Hormone Therapy Changes the Natural History of Body Composition and Motor Function in Children with Prader-Willi Syndrome

Author(s) -

Aaron L. Carrel,

S Myers,

Barbara Y. Whitman,

Jens C. Eickhoff,

David B. Allen

Publication year - 2010

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2009-1389

Subject(s) - medicine , endocrinology , lean body mass , hypotonia , natural history , fat mass , obesity , body weight

Children with Prader-Willi syndrome (PWS) have decreased muscle mass, hypotonia, and impaired linear growth. Recombinant human GH (hGH) treatment reportedly improves body composition and physical function in children with PWS, but these studies lack long-term control data. To assess the impact of hGH therapy begun early in life on the natural history of PWS, we compared height, body composition, and strength in similar-age children with PWS naïve to hGH with those treated with hGH for 6 yr.

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