Open AccessNerve Growth Factor Induces Vascular Endothelial Growth Factor Expression in Granulosa Cells via a trkA Receptor/Mitogen-Activated Protein Kinase-Extracellularly Regulated Kinase 2-Dependent Pathway
Author(s) -
Marcela JulioPieper,
Patricia Lozada,
Verónica Tapia,
Margarita Vega,
Carlos Roberto de Resende Miranda,
David Vantman,
Sergio R. Ojeda,
Carmen Romero
Publication year - 2009
Publication title -
the journal of clinical endocrinology and metabolism/journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2009-0542
Subject(s) - tropomyosin receptor kinase a , nerve growth factor , endocrinology , medicine , vascular endothelial growth factor , angiogenesis , low affinity nerve growth factor receptor , vascular endothelial growth factor a , tyrosine kinase , signal transduction , receptor , mapk/erk pathway , phosphorylation , receptor tyrosine kinase , biology , chemistry , microbiology and biotechnology , vegf receptors
Acquisition of ovulatory competence by antral follicles requires development of an adequate vascular supply. Although it is well established that ovarian angiogenesis is cyclically regulated by vascular endothelial growth factor (VEGF), the factors controlling VEGF production by ovarian follicles remain largely unknown. Nerve growth factor (NGF) may be one of these factors, because NGF promotes angiogenesis and synthesis of angiogenic factors in other tissues and is produced by human granulosa cells (hGCs).