Open AccessSimvastatin Protects against the Development of Endometriosis in a Nude Mouse Model
Author(s) -
Kaylon L. BrunerTran,
Kevin G. Osteen,
Antoni J. Dulęba
Publication year - 2009
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2008-2802
Subject(s) - simvastatin , endometriosis , nude mouse , ovariectomized rat , medicine , matrix metalloproteinase , angiogenesis , infertility , endocrinology , andrology , pharmacology , estrogen , biology , cancer , pregnancy , genetics
Endometriosis is a common condition associated with infertility and pelvic pain in women. Recent in vitro studies have shown that statins decrease proliferation of endometrial stroma (ES) and inhibit angiogenesis.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom