TheTRIB3Q84R Polymorphism and Risk of Early-Onset Type 2 Diabetes | Zendy

Sabrina Prudente | Zendy; Daniela Scarpelli | Zendy; Manisha Chandalia | Zendy; Yuanyuan Zhang | Zendy; Eleonora Morini | Zendy; S Del Guerra | Zendy; Francesco Perticone | Zendy; Rong Li | Zendy; Christine Powers | Zendy; Francesco Andreozzi | Zendy; Piero Marchetti | Zendy; Bruno Dallapiccola | Zendy; Nicola Abate | Zendy; Alessandro Doria | Zendy; Giorgio Sesti | Zendy; Vincenzo Trischitta | Zendy

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TheTRIB3Q84R Polymorphism and Risk of Early-Onset Type 2 Diabetes

Author(s) -

Sabrina Prudente,

Daniela Scarpelli,

Manisha Chandalia,

Yuanyuan Zhang,

Eleonora Morini,

S Del Guerra,

Francesco Perticone,

Rong Li,

Christine Powers,

Francesco Andreozzi,

Piero Marchetti,

Bruno Dallapiccola,

Nicola Abate,

Alessandro Doria,

Giorgio Sesti,

Vincenzo Trischitta

Publication year - 2008

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2008-1365

Subject(s) - medicine , type 2 diabetes , endocrinology , insulin , odds ratio , diabetes mellitus , context (archaeology) , confidence interval , glucose tolerance test , insulin resistance , biology , paleontology

The prevalence of type 2 diabetes (T2D), particularly among young adults, has been rising steadily during the past 2 decades. T2D, especially in its early-onset subtype, is under genetic control. TRIB3 inhibits insulin-stimulated Akt phosphorylation and subsequent insulin action. A TRIB3 gain-of-function polymorphism, Q84R (rs2295490), impairs insulin signaling.

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