Weight Loss Improves β-Cell Function in People With Severe Obesity and Impaired Fasting Glucose: A Window of Opportunity | Zendy

Amy E. Rothberg | Zendy; William H. Herman | Zendy; Chun-Yi Wu | Zendy; Heidi B. IglayReger | Zendy; Jeffrey F. Horowitz | Zendy; Charles Burant | Zendy; Andrzej T. Gałecki | Zendy; Jeffrey B. Halter | Zendy

Open Access

Weight Loss Improves β-Cell Function in People With Severe Obesity and Impaired Fasting Glucose: A Window of Opportunity

Author(s) -

Amy E. Rothberg,

William H. Herman,

Chun-Yi Wu,

Heidi B. IglayReger,

Jeffrey F. Horowitz,

Charles Burant,

Andrzej T. Gałecki,

Jeffrey B. Halter

Publication year - 2019

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/clinem/dgz189

Subject(s) - impaired fasting glucose , weight loss , medicine , type 2 diabetes , obesity , insulin resistance , body mass index , endocrinology , diabetes mellitus , insulin , impaired glucose tolerance

In people with obesity, β-cell function may adapt to insulin resistance. We describe β-cell function in people with severe obesity and normal fasting glucose (NFG), impaired fasting glucose (IFG), and type 2 diabetes (T2DM), as assessed before, 3 to 6 months after, and 2 years after medical weight loss to describe its effects on insulin sensitivity, insulin secretion, and β-cell function.

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