Open AccessNew Horizon: Exercise and a Focus on Tissue-Brain Crosstalk
Author(s) -
Logan K. Townsend,
Rebecca E. K. MacPherson,
David C. Wright
Publication year - 2021
Publication title -
the journal of clinical endocrinology and metabolism/journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/clinem/dgab333
Subject(s) - crosstalk , neuroscience , brain function , medicine , population , brain tissue , endocrinology , physical exercise , bioinformatics , psychology , biology , physics , environmental health , optics
The world population is aging, leading to increased rates of neurodegenerative disorders. Exercise has countless health benefits and has consistently been shown to improve brain health and cognitive function. The purpose of this review is to provide an overview of exercise-induced adaptations in the brain with a focus on crosstalk between peripheral tissues and the brain. We highlight recent investigations into exercise-induced circulating factors, or exerkines, including irisin, cathepsin B, GPLD1, and ketones and the mechanisms mediating their effects in the brain.