Open AccessA Polygenic Risk Score to Predict Future Adult Short Stature Among Children
Author(s) -
Tianyuan Lu,
Vincenzo Forgetta,
Haoyu Wu,
John R. B. Perry,
Ken K. Ong,
Celia Greenwood,
Nicholas J. Timpson,
Despoina Manousaki,
J. Brent Richards
Publication year - 2021
Publication title -
the journal of clinical endocrinology and metabolism/journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/clinem/dgab215
Subject(s) - demography , cohort , medicine , biobank , longitudinal study , polygenic risk score , receiver operating characteristic , cohort study , population , short stature , framingham risk score , pediatrics , biology , genetics , single nucleotide polymorphism , genotype , environmental health , pathology , sociology , gene , disease
Adult height is highly heritable, yet no genetic predictor has demonstrated clinical utility compared to mid-parental height.