Open AccessTumor DNA Mutations From Intraparenchymal Brain Metastases Are Detectable in CSF
Author(s) -
Stephanie Cheok,
Azeet Narayan,
Anna Arnal-Estapé,
Scott Gettinger,
Sarah B. Goldberg,
Harriet M. Kluger,
Don X. Nguyen,
Abhijit A. Patel,
Veronica Chiang
Publication year - 2021
Publication title -
jco precision oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.405
H-Index - 22
ISSN - 2473-4284
DOI - 10.1200/po.20.00292
Subject(s) - medicine , cerebrospinal fluid , pathology , brain metastasis , cell free fetal dna , lung cancer , cancer , oncology , metastasis , biology , pregnancy , fetus , prenatal diagnosis , genetics
Discordant responses between brain metastases and extracranial tumors can arise from branched tumor evolution, underscoring the importance of profiling mutations to optimize therapy. However, the morbidity of brain biopsies limits their use. We investigated whether cell-free DNA (cfDNA) in CSF could serve as an effective surrogate marker for genomic profiling of intraparenchymal (IP) brain metastases.