Genome-Wide Epigenetic Landscape of Lung Adenocarcinoma Links HOXB9 DNA Methylation to Intrinsic EGFR-TKI Resistance and Heterogeneous Responses | Zendy

ShengFang Su | Zendy; Chia-Hsin Liu | Zendy; Chiou-Ling Cheng | Zendy; ChaoChi Ho | Zendy; TsungYing Yang | Zendy; KunChieh Chen | Zendy; Kuo-Hsuan Hsu | Zendy; JengSen Tseng | Zendy; HueiWen Chen | Zendy; GeeChen Chang | Zendy; SungLiang Yu | Zendy; Ker-Chau Li | Zendy

Open Access

Genome-Wide Epigenetic Landscape of Lung Adenocarcinoma Links HOXB9 DNA Methylation to Intrinsic EGFR-TKI Resistance and Heterogeneous Responses

Author(s) -

ShengFang Su,

Chia-Hsin Liu,

Chiou-Ling Cheng,

ChaoChi Ho,

TsungYing Yang,

KunChieh Chen,

Kuo-Hsuan Hsu,

JengSen Tseng,

HueiWen Chen,

GeeChen Chang,

SungLiang Yu,

Ker-Chau Li

Publication year - 2021

Publication title -

jco precision oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.405

H-Index - 22

ISSN - 2473-4284

DOI - 10.1200/po.20.00151

Subject(s) - dna methylation , epigenetics , methylation , cancer research , epidermal growth factor receptor , cpg site , adenocarcinoma , epigenomics , biology , lung cancer , medicine , oncology , gene , genetics , cancer , gene expression

Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) show efficacy in treating patients with lung adenocarcinoma with EGFR -activating mutations. However, a significant subset of targeted patients fail to respond. Unlike acquired resistance (AR), intrinsic resistance (IR) remains poorly understood. We investigated whether epigenomic factors contribute to patient-to-patient heterogeneity in the EGFR-TKI response and aimed to characterize the IR subpopulation that obtains no benefit from EGFR-TKIs.

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