Open AccessMutation Rates in Cancer Susceptibility Genes in Patients With Breast Cancer With Multiple Primary Cancers
Author(s) -
Kara N. Maxwell,
Brandon M. Wenz,
Abha Kulkarni,
Bradley Wubbenhorst,
Kurt D’Andrea,
Benita Weathers,
N Goodman,
Joseph Vijai,
Jenna Lilyquist,
Steven N. Hart,
Thomas P. Slavin,
Kasmintan A. Schrader,
Vignesh Ravichandran,
Tinu Thomas,
Chunling Hu,
Mark E. Robson,
Paolo Peterlongo,
Bernardo Bonanni,
James M. Ford,
Judy E. Garber,
Susan L. Neuhausen,
Payal D. Shah,
Angela R. Bradbury,
Angela DeMichele,
Kenneth Offit,
Jeffrey N. Weitzel,
Fergus J. Couch,
Susan M. Domchek,
Katherine L. Nathanson
Publication year - 2020
Publication title -
jco precision oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.405
H-Index - 22
ISSN - 2473-4284
DOI - 10.1200/po.19.00301
Subject(s) - breast cancer , medicine , cancer , oncology , germline mutation , palb2 , mutation , mutation rate , genetics , biology , population , gene , environmental health
Women with breast cancer have a 4%-16% lifetime risk of a second primary cancer. Whether mutations in genes other than BRCA1/2 are enriched in patients with breast and another primary cancer over those with a single breast cancer (S-BC) is unknown.