Unique Genomic Landscape of High-Grade Neuroendocrine Cervical Carcinoma: Implications for Rethinking Current Treatment Paradigms | Zendy

Ramez N. Eskander | Zendy; Julia A. Elvin | Zendy; Laurie M. Gay | Zendy; Jeffrey S. Ross | Zendy; Vincent A. Miller | Zendy; Razelle Kurzrock | Zendy

Open Access

Unique Genomic Landscape of High-Grade Neuroendocrine Cervical Carcinoma: Implications for Rethinking Current Treatment Paradigms

Author(s) -

Ramez N. Eskander,

Julia A. Elvin,

Laurie M. Gay,

Jeffrey S. Ross,

Vincent A. Miller,

Razelle Kurzrock

Publication year - 2020

Publication title -

jco precision oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.405

H-Index - 22

ISSN - 2473-4284

DOI - 10.1200/po.19.00248

Subject(s) - pten , cohort , cancer research , cdkn2b , oncology , malignancy , msh2 , medicine , biology , arid1a , amplicon , pi3k/akt/mtor pathway , cancer , cdkn2a , gene , genetics , apoptosis , mutation , colorectal cancer , polymerase chain reaction , dna mismatch repair

High-grade neuroendocrine cervical cancer (HGNECC) is an uncommon malignancy with limited therapeutic options; treatment is patterned after the histologically similar small-cell lung cancer (SCLC). To better understand HGNECC biology, we report its genomic landscape.

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